| Evidence-based treatment protocols | Guide recommendation |
First line drugs | Lithium salt + valproic acid | Naltrexone added to conventional treatment |
Treatment of emotional symptoms | ||
Lithium salts (teenagers) | If taking lithium salts, add valproic acid | |
Taking naltrexone to reduce alcohol consumption | ||
Second line drugs | None | Lamotrigine monotherapy or add-on therapy |
Valproic acid monotherapy or add-on therapy | ||
Addition of disulfiram | ||
If naltrexone is not effective in helping patients to quit drinking, switch to acamprosate | ||
Three lines drugs | None | Add gabapentin |
Addition of topiramate | ||
|
| Lithium salt |
If acamprosate and naltrexone do not work to stop drinking, consider disulfiram | ||
Drugs with insufficient evidence | Acetic acid | None |
Aripiprazole | ||
Gabapentin | ||
Icariside | ||
Lamotrigine | ||
Naltrexone | ||
Topiramate | ||
Disulfiram | ||
No medication recommended | Quetiapine monotherapy or add-on therapy | Quetiapine monotherapy or add-on therapy |