Suggestions for pharmacological treatment of depressive episodes with mixed features

Drug selection

Drug recommendations

Single drug

Valproate, lithium salt, quetiapine

Suitable for

Valproate/Lithium + quetiapine/olanzapine

Not recommended

Antidepressants (for bipolar depressed patients, transcranial magnetic stimulation combined with mood stabilizers has a lower risk of transient mania compared to antidepressants)