Parameter

Conventional HPLC column

Core shell HPLC column

Elution time for Imp.9 (min)

52.3

25.3

Flow rate (mL/min)

1.0

1.0

Injection volume (µL)

20

10

Run time (min)

60

40

Tailing Factor (for Imp.9)

0.93

0.98

USP Plate Count (for Imp.9)

52,499

362,211