|
| Intra-day (n = 6) | Inter-day (n = 6) | ||||
Analytes | Conc. spiked (ng/mL) | Conc. measured (mean ± SD) (µg/mL) | Precision (%) | Accuracy (%) | Conc. measured (mean ± SD) (µg/mL) | Precision (%) | Accuracy (%) |
Diclofenac | 5 | 4.3 ± 0.6 | 13.2 | 86.7 | 4.9 ± 0.8 | 16.9 | 98.6 |
10 | 8.6 ± 0.7 | 8.2 | 86.2 | 9.3 ± 1.0 | 11.0 | 93.0 | |
50 | 51.2 ± 6.0 | 11.7 | 102.4 | 48.2 ± 6.4 | 13.4 | 96.4 | |
150 | 139.7 ± 23.0 | 16.5 | 93.1 | 130.5 ± 18.3 | 14.1 | 87.0 | |
Fenoprofen | 5 | 5.9 ± 0.2 | 4.1 | 117.0 | 4.7 ± 0.9 | 19.8 | 94.2 |
10 | 9.8 ± 0.6 | 6.0 | 98.1 | 9.4 ± 0.4 | 4.7 | 93.7 | |
50 | 52.8 ± 3.2 | 6.1 | 105.6 | 47.9 ± 4.5 | 9.4 | 95.8 | |
150 | 146.4 ± 14.3 | 9.8 | 97.6 | 133.2 ± 8.7 | 6.6 | 88.8 | |
Flufenamic acid | 5 | 4.4 ± 0.9 | 21.1 | 87.1 | 4.4 ± 1.1 | 24.7 | 88.5 |
10 | 5.5 ± 1.3 | 24.5 | 54.6 | 8.1 ± 2.5 | 30.4 | 80.9 | |
50 | 43.0 ± 7.5 | 17.5 | 85.9 | 46.9 ± 8.7 | 18.5 | 93.8 | |
150 | 102.7 ± 40.0 | 38.9 | 68.5 | 112.8 ± 37.0 | 32.8 | 75.2 | |
Flunixin | 5 | 5.0 ± 0.3 | 6.4 | 100.5 | 5.2 ± 0.6 | 11.0 | 104.7 |
10 | 10.3±0.9 | 9.0 | 103.4 | 11.0 ± 1.0 | 9.3 | 110.2 | |
50 | 52.4±2.4 | 4.7 | 104.9 | 52.5 ± 4.2 | 8.1 | 104.9 | |
150 | 145.9±15.0 | 10.3 | 97.3 | 142.7 ± 13.3 | 9.4 | 95.1 | |
Indomethacin | 5 | 4.5 ± 0.6 | 13.6 | 90.2 | 4.8 ± 0.8 | 16.9 | 95.9 |
10 | 8.5 ± 0.6 | 7.2 | 84.8 | 8.9 ± 0.4 | 4.8 | 88.7 | |
50 | 49.0 ± 5.4 | 11.1 | 98.0 | 47.6 ± 7.8 | 16.3 | 95.3 | |
150 | 130.1 ± 20.3 | 15.6 | 86.8 | 129.5 ± 21.5 | 16.6 | 86.4 | |
Indoprofen | 5 | 5.1 ± 0.4 | 7.1 | 101.1 | 5.1 ± 0.2 | 4.5 | 101.9 |
10 | 10.3 ± 0.5 | 4.8 | 102.6 | 10.4 ± 0.9 | 8.4 | 103.8 | |
50 | 50.6 ± 2.4 | 4.8 | 101.2 | 53.1 ± 5.0 | 9.5 | 106.2 | |
150 | 146.1 ± 7.9 | 5.4 | 97.4 | 143.9 ± 9.2 | 6.4 | 95.9 | |
Ketoprofen | 5 | 5.2 ± 1.4 | 27.3 | 103.3 | 5.1 ± 0.8 | 14.9 | 102.1 |
10 | 9.9 ± 1.0 | 10.2 | 99.2 | 10.1 ± 0.9 | 8.4 | 101.4 | |
50 | 50.5 ± 2.0 | 4.0 | 101.1 | 50.0 ± 3.7 | 7.3 | 100.0 | |
150 | 140.6 ± 9.1 | 6.5 | 93.7 | 141.2 ± 11.7 | 8.3 | 94.2 | |
Ketorolac | 5 | 4.6 ± 0.2 | 3.9 | 92.3 | 5.0 ± 0.7 | 13.6 | 100.5 |
10 | 9.8 ± 0.7 | 7.2 | 98.0 | 10.0 ± 0.4 | 4.4 | 99.7 | |
50 | 46.4 ± 4.9 | 10.5 | 92.8 | 47.3 ± 5.8 | 12.3 | 94.5 | |
150 | 139.8 ± 4.4 | 3.1 | 93.2 | 146.8 ± 12.5 | 8.5 | 97.9 |