Study No.* | Treatment | Pseudoephedrine | Acetylsalicylic acid | Salicylic acid | ||||||||
Cmax (µg/L) | AUC0-∞ (µg × h/L) | Tmax (hours) | Cmax (µg/mL) | AUC0-∞ (µg × h/mL) | Tmax (hours) | Cmax (µg/mL) | AUC0-∞ (µg × h/mL) | Tmax (hours) | ||||
IMP 14892 | Aspirin Complex compared to experimental product | 147/21.6 (92.7 - 230) | 1110/27.4 (666 - 2215) | 0.83 (0.33 - 4.00) | 13.00/22.3 (8.9 - 24.5) | 7.87/18.4 (5.5 - 11.3) | 0.31 (0.17 - 0.53) | 24.30/15.6 (17.9 - 31.4) | 111.0/29.0 (72.5 - 209) | 0.83 (0.33-2.00) | ||
IMP 15776 | Aspirin Complex Hot Drink | 154/29.6 (90.3 - 291) | 921/24.2 (625 - 1886) | 0.83 (0.25 - 3.0) | 15.86/35.1 (8.1 - 30.5) | 8.94/15.5 (6.7 - 11.7) | 0.25 (0.15 - 0.50) | 27.75/17.9 (18.1 - 37.6) | 155.5/32.5 (92.4 - 326) | 0.67 (0.25-1.50) | ||
IMP 15776 | Aspirin Complex | 143/29.6 (85.8 - 257) | 952/26.1 (648 - 2035) | 0.83 (0.33 - 3.0) | 14.97/33.3 (5.4 - 24.6) | 9.17/15.0 (7.0 - 12.6) | 0.25 (0.17 - 0.67) | 27.08/15.0 (19.7 - 36.7) | 152.4/31.8 (96.8 - 331) | 0.91 (0.33-2.00) | ||
IMP 11757 | Aspirin Complex compared to experimental product | 122/24.7 (78.3 - 196.7) | 966/26.2 (611 - 1678) | 0.83 (0.33 - 3.0) | 12.57/34.0 (7.0 - 29.5) | 6.34/20.1 (4.7 - 9.7) | 0.25 (0.17 - 0.35) | 31.32/21.7 (21.1 - 43.5) | 133.8/22.8 (85.2 - 192) | 0.83 (0.42-2.00) | ||
Summary** | 141/1.1 (122-154) | 985/1.1 (921 - 1110) | 0.83 (0.83 - 0.83) | 14.03/1.1 (12.57 - 15.86) | 8.00/1.2 (6.34 - 9.17) | 0.26 (0.25 - 0.31 | 27.50/1.1 (24.30 - 31.32) | 137/1.1 (111.0 - 155.5) | 0.81 (0.67 - 0.91) | |||