Authors

Site of fracture

Study design

Results

Jansen J et al. (2011) [75]

Vertebral fractures

Meta-analysis of 8 RCTs

All BPs reduced the risk of fractures with zoledronate providing the greatest reduction of all BPs

Shi L et al. (2019) [76]

Vertebral fractures

Meta-analysis involving 11,822 patients with osteoporotic fractures

BPs significantly reduced the risk of new vertebral, and nonvertebral fractures with alendronate being the best intervention for secondary prevention than the other BPs

Climet v et al. [77]

Distal radial fractures

RCT

No statistically significant differences in fracture healing rate in alendronate and placebo groups with significantly improved bone mass in the alendronate group

Rosental et al. (2009) [78] and Shoji KE (2018) [79]

Distal radial fractures

RCT

No significant differences in fracture healing time, clinical or functional outcomes in conservatively treated DRF patients in BP users and BP naive patients.