Drug name

Dosing regimen

Adverse effects

Alendronate

10 mg/day or 70 mg per week orally

Gastrointestinal discomfort and acute influenza-like illness, acute phase reactions, ONJ, atypical fracture of the femoral head

Risedronate

5 mg/day or 35 mg per week orally

Ibandronate

2.5 mg/day or 150 mg per month orally

Zoledronate

5 mg yearly IV

Denosumab

60 mg SC once in six months

Serious infections, dermatitis, rashes, eczema and ONJ, atypical fracture of the femoral head

Raloxifene

60 mg daily orally

Skin rash, hot flushes, abdominal pain

Teriparatide

20 mcg daily SC

Hypercalcemia and hypercalciuria

Strontium ranelate

2 mg daily orally

Thromboembolism, skin rash