Product name Manufacturer | Product specifications and properties | Indications |
Strattice® Life Cell Corp, Brachburg, US | Introduced 2008, licensed in Europe and US, porcine-derived, non-crosslinked, undergoes a minimally manipulative manufacturing process with the aim to eliminate the alpha-Gal epitope, thickness 1 - 2 mm provides chemotaxis and suppresses apoptotic induction [37] loses tensile strength significantly in a mouse model between 30 days and 3 months [38] [39] Seems to elicit an intense early immune response in mouse models [40] [41] with later shift to beneficial M2:M1 ratio around day 35 [41] Observed collagen deposition at later time points in mouse models [38] [39] [40] | Breast Reconstruction Abdominal Wall Repair |
Epiflex ® DIZG mbH, Berlin, Germany | Human-skin derived, non crosslinked, thickness >0.3 and >0.8 mm [42] preservation of significant ECM components such as collagen type I, type III, type IV, fibronectin, laminin, vitronectin and hyaluronic acid seem to be preserved after decellularization, small amounts of donor DNA remain | Breast Reconstruction Hypertrophic Scar Treatment Dermis Replacement Soft Tissue Replacement |
Braxon® DECO med s.r.l., Venice, Italy | pre-shaped, non-crosslinked, 0.6 mm thick, porcine-derived matrix, shows mild fibroblastic reaction and ingrowth of blood vessels after 1 yr in humans [43] , no chemical preservatives used during manufacturing process | Breast Reconstruction |