Variable

Univariate analysis

Multivariate analysis

HR (95%CI)

p value

HR (95%CI)

p value

Age

1.469

(0.5446 - 3.962)

0.4476

after 6 months

1.0720

(1.00 - 1.146)

after 12 months

0.9955

(0.9426 - 1.051)

0.04^*

0.87

BSI change after

6 months (≤1 vs. ≥1)

5.841

(1.248 - 27.34)

0.025^*

12.76

(1.811 - 89.850)

0.01^*

BSI change after

12 months (≤1 vs. ≥1)

4.22

(1.176 - 15.15)

0.027^*

5.0640

(1.0590 - 24.220)

0.042^*

The number of BSI

(≤median vs. ≥median)

0.8479

(0.3177 - 2.263)

0.7418

The number of hot spots

(≤median vs. ≥median)

0.7881

(0.2861 - 2.171)

0.6451

Extraosseous metastasis at bone metastasis onset

0.935

(0.3233 - 2.704)

0.9013

CA15-3 change after

6 months (≤1 vs. ≥1)

1.652

(0.5524 - 4.939)

0.3692

0.9554

(0.2661 - 3.413)

0.944