Variable

No of patients

No of deaths

p value (Log Rank Test)

Age

(median 56)

≤56

≥56

28

29

7

9

0.374

BSI change after

6 months

≤1

≥1

20

23

2

9

0.011^*

BSI change after

12 months

≤1

≥1

25

23

3

11

0.016^*

The number of BSI

(median 0.676)

≤0.676

≥0.676

28

29

8

8

0.743

The number of hot spots

(median 7)

≤7

≥7

30

27

10

6

0.644

Extra osseous metastasis at bone metastasis onset

presence

absence

31

26

7

9

0.986

CA15-3 change after

6 months

≤1

≥1

28

20

6

7

0.364

CA15-3 change after

12 months

≤1

≥1

29

18

4

7

0.0534

CA15-3 normal or abnormal at bone metastasis onset

normal

abnormal

25

29

7

7

0.894

CEA change after

6 months

≤1

≥1

24

17

5

6

0.405

CEA change after

12 months

≤1

≥1

27

17

5

6

0.144

CEA normal or abnormal at bone metastasis onset

normal

abnormal

28

22

7

6

0.968

With hormone therapy or without hormone therapy

without

with

20

37

8

7

0.50

With anticancer drug or without anticancer drug.

without

with

19

38

3

13

0.301