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| there was complete compliance with the 6-hour bundle (OR 0.54; CI 95% 0.30 - 0.96, p = 0.033) and when there was complete compliance with all of the components of the 24-hour bundle (OR 0.37; CI 95% 0.24 - 0.58, p < 0.001). |
Cardoso et al. (2010) [35] | To evaluate the impact of compliance with a core version of the SSC 6-hour bundle on 28-day mortality. | Descriptive Cohort, multi-center, prospective study was conducted over one year. Patients were followed up until death or hospital discharge. | 17 ICUs in Portugal. | N = 778 Consecutive | 2004 to 2005 | Compliance with all actions 1 to 6 was associated with an OR of 0.44 [95% CI = 0.24 - 0.80] in severe sepsis and 0.49 (95% CI = 0.25 - 0.95) in septic shock, for 28-days mortality. Collecting blood cultures and giving vasopressors were significantly protective. |
Herrán-Monge et al. (2017) [36] | To determine the epidemiology and outcome of severe sepsis and septic shock after 9 years of the implementation of the SSC guidelines, and to build a mortality prediction model. | Quasi-experimental, Prospective, multicenter study was performed during a 5-month. Findings were compared with those obtained in the same ICUs in a study conducted in 2002. | 11 medical/ surgical ICUs in 10 teaching hospitals in Spain. | N = 262 Convenient | 2011 | The 2011 cohort had a marked reduction in 48-hour (7% vs 14.8%), ICU (27.2% vs 48.2%), and in-hospital (36.7% vs 54.3%) mortalities. The implementation of the SSC guidelines resulted in a marked decrease in the overall mortality. |