Authors

Purpose

Design

Settings

Sample size and sampling technique

Year of implementing the SSC guidelines

Main findings

Chou et al. (2014) [20]

To implement sepsis guidelines and examine their effect on patients with severe sepsis or septic shock in ICUs.

A prospective observational cohort design. The study had four phases: preintervention, education, operational and postintervention.

13-bed ICU in a tertiary medical center in southern Taiwan.

N = 164

Convenient

2010 to 2011

Implementation of the modified sepsis guidelines was successful in reduction of in-hospital mortality and hospital expenditure. In-hospital mortality rates were: 34.6% 10.0%, 23.1% and 24.5%, for Pre-intervention, education, operation and post-intervention phases, respectively (p < 0.05).

Pestana et al. (2010) [21]

To analyze the compliance with a sepsis guidelines and the impact of the fulfillment of different therapeutic guidelines on ICU survival in a cohort of surgical patients with septic shock.

Retrospective, observational descriptive design was used to consider compliance with seven quality indicators of sepsis bundle.

Surgical

ICUs in two University hospitals in Spain.

N = 182

Convenient

2003 and 2008

ICU survival was significantly related to the number of fulfilled therapeutic guidelines included in a sepsis bundle. (OR, 1.64; 95% CI, 1.28 - 2.1; p < 0.001; survival was higher in the bundle-compliant patients. Mortality rates were 56.8% and 36.8% for patients not treated by bundle and those treated based on the bundle, respectively.