Authors | Purpose | Design | Settings | Sample size and sampling technique | Year of implementing the SSC guidelines | Main findings |
Chou et al. (2014) [20] | To implement sepsis guidelines and examine their effect on patients with severe sepsis or septic shock in ICUs. | A prospective observational cohort design. The study had four phases: preintervention, education, operational and postintervention. | 13-bed ICU in a tertiary medical center in southern Taiwan. | N = 164 Convenient | 2010 to 2011 | Implementation of the modified sepsis guidelines was successful in reduction of in-hospital mortality and hospital expenditure. In-hospital mortality rates were: 34.6% 10.0%, 23.1% and 24.5%, for Pre-intervention, education, operation and post-intervention phases, respectively (p < 0.05). |
Pestana et al. (2010) [21] | To analyze the compliance with a sepsis guidelines and the impact of the fulfillment of different therapeutic guidelines on ICU survival in a cohort of surgical patients with septic shock. | Retrospective, observational descriptive design was used to consider compliance with seven quality indicators of sepsis bundle. | Surgical ICUs in two University hospitals in Spain. | N = 182 Convenient | 2003 and 2008 | ICU survival was significantly related to the number of fulfilled therapeutic guidelines included in a sepsis bundle. (OR, 1.64; 95% CI, 1.28 - 2.1; p < 0.001; survival was higher in the bundle-compliant patients. Mortality rates were 56.8% and 36.8% for patients not treated by bundle and those treated based on the bundle, respectively. |