Associated secretory biogenesis and mast cell phenotype

Type of SNARE protein responsible for vesicular trafficking

Ref.

1. Familial Lymphohystiocytosis (FLH) type

a. FLH1

Unknown

b. FLH2

Defect in cytotoxic granule protein perforin/pore forming protein

[87]

c. FLH3

Defects in SNARE accessory protein Munc13-4

[88]

d. FLH4

Defects in t-SNARE syntaxin-11

[89]

e. FLH5

Defects in SNARE accessory protein syntaxin Binding Protein-2 (Munc18-2) that belonging to SM family of fusion accessory protein

[90] [91]

2. Hermansky-Pudlak syndrome (HPS)

Pulmonary fibrosis―endosomes to lysosomes related defects

[92] [93]