Adverse effects

Group A (n = 20)

Group B (n = 20)

p value

Nausea

6 weeks

2 (10.0%)

14 (70.0%)

<0.001*

12 weeks

3 (15.0%)

19 (95.0%)

<0.001*

Vomiting

6 weeks

1 (5.0%)

4 (20.0%)

0.151

12 weeks

1 (5.0%)

18 (90.0%)

<0.001*

Abdominal pain

6 weeks

0 (0.0%)

1 (5.0%)

0.311

12 weeks

0 (0.0%)

3 (15.0%)

0.072

Restlessness

6 weeks

0 (0.0%)

1 (5.0%)

0.311

12 weeks

0 (0.0%)

6 (30.0%)

0.008*

Crying

6 weeks

0 (0.0%)

3 (15.0%)

0.072

12 weeks

0 (0.0%)

11 (55.0%)

<0.001*

Irritability

6 weeks

0 (0.0%)

1 (5.0%)

0.311

12 weeks

0 (0.0%)

5 (25.0%)

0.017*

Refusal to MTX

6 weeks

0 (0.0%)

1 (5.0%)

0.311

12 weeks

0 (0.0%)

2 (10.0%)

0.147