TOTAL

(n = 897)

Spring

(n = 202)

Summer

(n = 201)

Autumn

(n = 212)

Winter

(n = 282)

p^*

Male gender, n (%)

178 (59)

48 (63)

21 (41)

44 (70)

65n(59)

0.016^*

Age , median (IQR)

59 ± 17

59 ± 16

60 ± 17

55 ± 18

60 ± 18

0.297^§

SAPS II, median (IQR)

48 ± 16

51 ± 15

47 ± 17

44 ± 15

48 ± 16

0.076^§

Septic shock, n (%)

197 (66)

57 (75)

30 (59)

43 (68)

67 (61)

0.152^*

Comorbidities, n (%)

89 (30)

26 (34)

10 (20)

21 (33)

32 (29)

0.305^*

Focus of infection, n (%)

Respiratory

171 (57)

38 (50)

21 (41)

32 (51)

80 (73)

<0.001^*

Intra-abdominal

69 (23)

19 (25)

17 (33)

13 (21)

20 (18)

0.184^*

Urinary

24 (8)

6 (8)

8 (16)

8 (13)

2 (2)

0.004^&

Skin and soft tissue

12 (4)

2 (3)

2 (4)

4 (6)

4 (4)

0.730^&

Other

24 (8)

11 (15)

3 (6)

6 (10)

4 (4)

0.054^&

Microbiological documented, n (%)

168 (56)

46 (61)

24 (47)

38 (60)

60 (55)

0.419^*

Positive blood cultures, n (%)

59 (20)

17 (22)

10 (20)

13 (21)

19 (17)

0.855^*

Type of microorganism, n (%)

0.172^&

Gram positive

71 (42)

15 (33)

9 (438)

16 (42)

31 (52)

Gram negative

62 (37)

17 (37)

13 (54)

13 (34)

19 (32)

Others

35 (21)

14 (30)

2 (8)

9 (24)

10 (17)

ESKAPE

19 (11)

5 (11)

4 (17)

2 (5)

8 (13)

0.477^&

Polimcrobian, n (%)

20 (7)

7 (9)

2 (4)

5 (8)

6 (6)

0.630^&

Death in ICU, n (%)

100 (33)

27 (36)

15 (29)

17 (27)

41 (37)

0.491^*

Death in hospital, n (%)

111 (37)

31 (41)

15 (29)

18 (29)

47 (43)

0.159^*