Total

(n = 300)

Severe sepsis

(n = 98)

Septic shock

(n = 202)

p

Male gender, n (%)

178 (59)

62 (60)

116 (59)

0.826^*

Age, mean ± SD

59 ± 17

54 ± 18

61 ± 17

0.002^£

SAPS II, mean ± SD

48 ± 16

40 ± 13

52 ± 15

<0.001^£

Comorbidities, n (%)

89 (30)

26 (25)

63 (32)

0.225^*

Immunossupression

24 (8)

6 (6)

18 (9)

0.315^*

Chronic hepatic disease

10 (4)

3 (3)

10 (5)

0.553^&

Chronic renal disease

23 (8)

5 (5)

18 (9)

0.186^*

Chronic heart failure

18 (6)

7 (7)

11 (6)

0.675^*

Chronic respiratory disease

22 (7)

10 (10)

12 (6)

0.254^*

Haematologic disease

5 (2)

0 (0)

5 (3)

Cancer

5 (2)

0 (0)

5 (3)

Source of infection, n (%)

Respiratory

171 (57)

67 (65)

104 (53)

0.042^*

Intra-abdominal

69 (23)

20 (19)

49 (25)

0.286^*

Urinary

24 (8)

3 (3)

21 (11)

0.023^&

Skin and soft tissue

12 (4)

58 (18)

94 (22)

0.225^*

Other

24 (8)

8 (8)

16 (8)

0.914^*

Microbiological documented, n (%)

168 (56)

53 (52)

115 (58)

0.252^*

Positive blood cultures, n (%)

59 (20)

13 (13)

46 (23)

0.026^*

Type of microorganism, n (%)

0.474^&

Gram positive

71 (42)

23 (46)

48 (41)

Gram negative

62 (37)

15 (30)

47 (40)

Other

35 (21)

12 (24)

23 (20)

ESKAPE

19 (11)

5 (10)

14 (12)

1.000^&

Polimicrobian

20 (4)

8 (10)

12 (7)

0.050^*

ICU LOS, median (IQR)

8 (3 - 15)

6 (3 - 11)

9 (3 - 16)

0.001^#

Hospital LOS, median (IQR)

16 (7 - 27)

15 (8 - 24)

16 (5 - 28)

0.451^#

Death in ICU, n (%)

100 (33)

15 (15)

85 (43)

<0.001^*

Death in hospital, n (%)

111 (37)

21 (20)

90 (46)

<0.001^*