| Variables | Study cohort | 10-year CVD risk < 2% | 10-year CVD risk > 2% | P-value | |
| n (%) | 134 (100.0) | 108 (80.6) | 26 (19.4) | - | |
| Age, years, mean (SD) | 39.4 (7.8) | 36.8 (6.0) | 50.0 (4.5) | <0.001 | |
| Exposure duration, years, mean (SD) | 11.5 (5.9) | 10.6 (5.4) | 15.2 (6.6) | 0.001 | |
| Exposure duration (tertiles) |
|
|
|
| |
| 1st (<8 years), n (%) | 45 (33.6) | 40 (37.0) | 5 (19.2) |
| |
| 2nd (8 - 14 years), n (%) | 46 (34.3) | 40 (37.0) | 6 (23.1) | 0.008 | |
| 3rd (>14 years), n (%) | 43 (32.1) | 28 (25.9) | 15 (57.7) |
| |
| BMI, kg/m2, mean (SD) | 23.5 (3.9) | 23.4 (4.0) | 24.3 (3.4) | 0.115 | |
| SBP, mmHg, mean (SD) | 134.2 (18.8) | 132.4 (18.2) | 141.7 (19.7) | 0.025 | |
| DBP, mmHg, mean (SD) | 84.7 (13.2) | 84.0 (13.3) | 87.7 (12.4) | 0.174 | |
| Hypertension, n (%) | 63 (47.0) | 48 (44.4) | 15 (57.7) | 0.224 | |
| Creatinine, mg/L, mean (SD) | 11.5 (1.3) | 11.6 (1.3) | 11.6 (1.4) | 0.844 | |
| ALP, UI/L, median (IQR) | 63.0 (51.0 - 78.0) | 62.5 (49.0 - 77.0) | 68.0 (55.0 - 85.0) | 0.176 | |
| ALT, UI/L, median (IQR) | 12.0 (9.0 - 15.0) | 12.0 (9.0 - 16.0) | 12.0 (8.0 - 13.0) | 0.384 | |
| AST, UI/L, median (IQR) | 29.0 (26.0 - 35.3) | 29.0 (26.0 - 36.0) | 30.0 (28.0 - 33.0) | 0.571 | |
| Glucose, mmol/L, mean (SD) | 4.2 (0.6) | 4.2 (0.6) | 4.3 (0.9) | 0.746 | |
| Insulin, µU/mL, median (IQR) | 19.6 (14.2 - 32.5) | 19.4 (14.2 - 31.2) | 20.6 (14.2 - 35.9) | 0.826 | |
| HOMA-IR, median (IQR) | 3.6 (2.6 - 6.1) | 3.6 (2.6 - 5.6) | 3.9 (2.4 - 6.4) | 0.706 | |
| CRP, mg/L, median (IQR) | 1.7 (0.6 - 3.6) | 1.7 (0.6 - 3.7) | 1.8 (0.6 - 3.4) | 0.769 | |
| Uric acid, µmol/L, median (IQR) | 351.1 (297.5 - 392.7) | 351.1 (291.6 - 392.7) | 363.0 (315.4 - 386.8) | 0.585 | |
| TC, mmol/L, mmol/L, mean (SD) | 4.3 (0.9) | 4.2 (0.9) | 4.7 (1.2) | 0.027 | |
| TG, mmol/L, median (IQR) | 0.7 (0.5 - 1.0) | 0.7 (0.5 - 0.9) | 0.9 (0.7 - 1.1) | 0.011 | |
| HDL-C, mmol/L, mean (SD) | 1.3 (0.4) | 1.4 (0.4) | 1.3 (0.4) | 0.218 | |
| LDL-C, mmol/L, median (IQR) | 2.5 (2.0 - 3.1) | 2.5 (2.0 - 3.0) | 3.0 (2.2 - 3.6) | 0.013 | |
| Iron, µmol/L, median (IQR) | 16.3 (12.8 - 19.9) | 16.1 (12.4 - 19.4) | 17.5 (13.4 - 22.4) | 0.092 | |
| Potassium, mmol/L, median (IQR) | 4.5 (4.1 - 4.9) | 4.5 (4.2 - 5.1) | 4.4 (4.0 - 4.7) | 0.232 | |
| Alcohol intake, n (%) | 51 (38.1) | 40 (78.4) | 11 (21.6) | 0.619 | |
| Framingham 10-year CVD risk (%) *, median (IQR) | 1.0 (0.0 - 2.0) | 0.0 (0.0 - 1.0) | 5.0 (4.0 - 6.5) | <0.001 | |
| Framingham 10-year CVD risk (%), mean (95% CI) | 1.6 (1.2 - 2.0) | 0.6 (0.5 - 0.8) | 5.6 (4.7 - 6.5) |
| |
| Framingham 10-year CVD risk, n (%) |
|
|
|
| |
| Low (<10%) | 131 (97.8) | - | - | - | |
| Moderate (10% - 20%) | 3 (2.2) | - | - | - | |
| High (>20%) | 0 (0.0) | - | - | - | |