Cut-off values

SN %

(95% CI)

SP %

(95% CI)

PPV %

(95% CI)

NPV %

(95% CI)

Accuracy

(95% CI)

AUROC

(95% CI)

p-value

Pre-CRT

TLC

>5200 cell/µL

88.9%

(65.3 - 98.6)

54.6%

(32.2 - 75.6)

61.5%

(40.1 - 80.1)

85.7%

(57.2 - 98.2)

70%

(47.1 - 86)

0.692

(0.526 - 0.828)

0.03

Lymphocytes

>1850 cell/µL

94.4%

(72.7 - 99.9)

59.1%

(36.4 - 79.3)

65.4%

(44.3 - 82.8)

92.9%

(66.1 - 99.8)

75%

(52.7 - 88.6)

0.749

(0.587 - 0.872)

0.02

T cells

>1310 cell/µL

88.9%

(65.3 - 98.6)

54.6%

(32.2 - 75.6)

61.5%

(40.1 - 80.1)

85.7%

(57.2 - 98.2)

70%

(47.1 - 86)

0.764

(0.603 - 0.883)

<0.01

T helper

>971 cell/µL

94.4%

(72.7 - 99.9)

59.1%

(36.4 - 79.3)

65.4%

(44.3 - 82.8)

92.9%

(66.1 - 99.8)

75%

(52.7 - 88.6)

0.758

(0.596 - 0.879)

<0.01

T cytotoxic >460 cell/µL

55.6%

(30.8 - 78.5)

95.5%

(77.2 - 99.9)

90.9%

(56.6 - 99.8)

72.4%

(52.4 - 87.5)

77.5%

(56.3 - 90.3)

0.750

(0.588 - 0.873)

0.02

Post-CRT

TLC

>5300 cell/µL

77.8%

(52.4 - 93.6)

77.3%

(54.6 - 92.2)

73.7%

(48.8 - 90.9)

81%

(57.4 - 94.8)

77.5%

(53.6 - 92.8)

0.745

(0.583 - 0.869)

0.02

ANC

>2500 cell/µL

77.8%

(52.4 - 93.6)

68.2%

(45.1 - 86.1)

66.7%

(43 - 85.4)

78.9%

(53.6 - 94.2)

72.5%

(48.4 - 89.5)

0.702

(0.537 - 0.836)

0.02

Lymphocytes

≤36.2%

88.9%

(65.3 - 98.6)

54.6%

(32.2 - 75.6)

61.5%

(40.1 - 80.1)

85.7%

(57.2 - 98.2)

70%

(47.1 - 86)

0.703

(0.538 - 0.837)

0.02

NLR

>1.47

77.8%

(52.4 - 93.6)

68.2%

(45.1 - 86.1)

66.7%

(43 - 85.4)

78.9%

(53.6 - 94.2)

72.5%

(48.4 - 89.5)

0.756

(0.595 - 0.878)

0.01