Alternatives to post-gadolinium MRI to differentiate true progression from PsP

Methods

Numbered References (refer to bibliography)

Dynamic O-(2-[18F]fluoroethyl)-L-Tyrosine PET

[29] [90] [97]

Dynamic contrast enhanced T1 magnetic resonance imaging (DCE MRI) (enhanced with i.e. ferumoxytol)

[30] [32] [89] [93] [95]

Cut-off values of apparent diffusion coefficients (ADCs)

[88] (ADC mean value ≤ 1300 × 10−6  mm2/s)

[96] (ADC1000 ≤ 929 × 10−6 mm2/sec, ADC3000 ≤ 645 × 10−6 mm2/sec)

[94] (ADC 5th percentile value 892 ×10−6 mm2/sec, 907 ×10−6 mm2/sec)

Multi-parameter aggregation and analysis

[91] - [93]