|
| BY BOLUS | BY 21 DAY | By 6 DAY |
| Total Dose required |
| Infusion | Infusion |
| So that retained dose in |
|
|
|
| Hematopoietic Tissue = |
|
|
|
| 100 U | 143 U | 250 U | 183 U |
| Retained BY Hematopoietic | 100 U | 100 U | 100 U |
| Tissue {DLT} |
|
|
|
| Retained by GUT | 236 U | 82 U | 106 U |
|
| When 143 total | When 250 total | When 183 total |
|
| Units given | Units given | Units given |
| Retained by ORAL | 104 U | 132 U | 125 U |
| MUCOSA | When 143 total | When 250 total | When 183 total |
|
| Units given | Units given | Units given |
| Retained By HEART | 79 U | 139 U | 94 U |
|
| When 143 Total | When 250 total | When 183 total |
|
| Units Given | Units given | Units given |