Rats

Cough Reflexes/5min

Control

10 mg/kg

20 mg/kg

50 mg/kg

100 mg/kg

200 mg/kg

300 mg/kg

Female

210 ± 23

234 ± 24

202 ± 28

186 ± 60

167 ± 6

165 ± 11

142 ± 13**

Male

227 ± 25

206 ± 31

210 ± 22

196 ± 18

146 ± 11

167 ± 5*

133 ± 19***