Rats

Dose

(mg/kg)

Blood Chemistry

ALT

ALP

GGT

T-bilib

D-bilib

Prot

Urea

Creat

Female

Control

38 ± 5

213 ± 9

1.4 ± 1

0.2 ± 0.03

0.6 ± 0.1

4 ± 0.4

26 ± 6

1.1 ± 0.1

20

35 ± 6

127 ± 4

1 ± 1

0.3 ± 0.04

0.4 ± 0.01

4 ± 0.3

22 ± 2

0.7 ± 1

500

40 ± 5

261 ± 57

1.2 ± 0.5

0.4 ± 0.03

0.3 ± 0.04

5 ± 0.5

30 ± 4

1.1 ± 0.1

1000

33 ± 6

192 ± 22

1.2 ± 0.2

0.4 ± 0.2

0.4 ± 0.03

4 ± 0.04

28 ± 3

1.1 ± 0.01

Male

Control

46 ± 5

238 ± 24

2 ± 1

0.2 ± 0.04

0.5 ± 0.2

5.7 ± 0.8

28 ± 4

0.7 ± 0.1

20

47 ± 4

217 ± 17

1 ± 0.2

0.4 ± 0.03

0.6 ± 0.2

4.6 ± 0.2

30 ± 3

0.5 ± 0.1

500

49 ± 4

180 ± 10

2.4 ± 0.4

0.3 ± 0.04

0.6 ± 0.1

4.7 ± 0.4

30 ± 4

0.6 ± 0.1

1000

45 ± 13

241 ± 14

1 ± 0.4

0.4 ± 0.1

0.3 ± 0.2

5.17 ± 2

28 ± 3

0.7 ± 0.1