EORTC/RTOG classification (European Organization for Research and Treatment of Cancer/RTOG: Radiation Therapy Oncology Group)

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Slight epithelial atrophy; minor telangiectasia; microscopic hematuria

Moderate frequency, generalized telangiectasia; intermittent macroscopic hematuria

Severe frequency and dysuria, generalized telangiectasia (often with petechiae), frequent hematuria with decreased bladder capacity

Necrosis/contracted bladder, severe hemorrhagic cystitis

Death directly due to hemorrhagic cystitis