Variable

Number total N (number of Non-users/users)

−Beta-blockade

+Beta-blockade

Significance p value (between-group)

Change during three months of intervention

MDI, mean (SD)

177 (75/102)

−2.8 (5.2)^*

−0.4 (4.1)

p = 0.003

MDI, mean (SD) for patients with MDI ≥ 15 at baseline

33 (17/16)

−9.1 (6.5)^*

−1.8 (6.2)

p = 0.009

Resting PPS, mean (SD)

177 (75/102)

−10 (17)^*

−14 (24)^*

n.s

PPS response to TTT, mean (SD)

177 (75/102)

3.0 (16)

2.8 (19)

n.s

SBP response to TTT , mean (SD)

177 (75/102)

2.4 mmHg

0.7 mmHg

n.s.

Correlations between changes during 3 months of intervention

Change in MDI score versus change in resting PPS

177 (75/102)

−0.09

−0.08

n.s

Change in MDI score versus change resting PPS for patients with MDI ≥15 at baseline

33 (17/16)

−0.69^*

−0.04

p = 0.05

Change in MDI score versus change in PPS response to TTT

177 (75/102)

−0.02

0.37^*

p = 0.02

Change in MDI score versus change in PPS response to TTT for patients with MDI ≥ 15 at baseline

33 (17/16)

−0.43

0.54^*

p = 0.02

Change in resting PPS versus change in PPS response to TTT

177 (75/102)

0.37^*

0.59^*

n.s

Change in resting PPS versus change in SBP response to TTT

177 (75/102)

0.32^*

+ 0.13

P = 0.004