Phase

Acute

Induction

Washout

Expression

Experimental Day (ED)

1

2 - 7

8 - 10

11

A. Adolescent―Age (days)

40

41 - 46

47 - 49

50

Exp. Group

1 (n = 8)

Saline

0.6 mg/kg MPD

Washout

0.6 mg/kg

2 (n = 11)

Saline

2.5 mg/kg MPD

Washout

2.5 mg/kg

3 (n = 8)

Saline

10.0 mg/kg MPD

Washout

10.0 mg/kg

4 (n = 8)

Saline

Saline

Washout

Saline

B. Adult―Age (days)

70

71 - 76

77 - 79

80

5 (n = 8)

Saline

0.6 mg/kg MPD

Washout

0.6 mg/kg

6 (n = 13)

Saline

2.5 mg/kg MPD

Washout

2.5 mg/kg

7 (n = 8)

Saline

10.0 mg/kg MPD

Washout

10.0 mg/kg

8 (n = 8)

Saline

Saline

Washout

Saline