Naranjo Algorithm: Pazopanib | ||||
Question | Yes | No | Do Not Know | Score |
1) Are there previous conclusive reports on this reaction? | +1 | 0 | 0 | |
2) Did the adverse event appear after the suspected drug was administered? | +2 | −1 | 0 | |
3) Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered? | +1 | 0 | 0 | |
4) Did the adverse event reappear when the drug was re-administered? | +2 | −1 | 0 | |
5) Are there alternative causes (other than the drug) that could on their own have caused the reaction? | −1 | +2 | 0 | |
6) Did the reaction reappear when a placebo was given? | −1 | +1 | 0 | |
7) Was the drug detected in blood (or other fluids) in concentrations known to be toxic? | +1 | 0 | 0 | |
8) Was the reaction more severe when the dose was increased or less severe when the dose was decreased? | +1 | 0 | 0 | |
9) Did the patient have a similar reaction to the same or similar drugs in any previous exposure? | +1 | 0 | 0 | |
10) Was the adverse event confirmed by any objective evidence? | +1 | 0 | 0 | |
TOTAL | 5 |