Entry | Catalyst | Amount of catalyst (equiv) | Solvent | Time (h) | Yield (%) | eea (%) |
1 | 1 | 0.3 | H2O | 0.5 | 98 | 86 (R) |
2 | 1 | 0.1 | H2O | 0.5 | 90 | 89 (R) |
3 | 1 | 0.05 | H2O | 2 | 82 | 89 (R) |
4 | 1 | 0.1 | DMSO | 48 | 11 | 19 (R) |
5 | 2 | 0.3 | H2O | 0.5 | 98 | 89 (S) |
6 | 2 | 0.1 | H2O | 0.5 | 89 | 91 (S) |
7 | 2 | 0.05 | H2O | 2 | 81 | 87 (S) |
8 | 2 | 0.1 | DMSO | 48 | 23 | 31 (S) |
9 | 3 | 0.3 | H2O | 24 | 32 | 83 (R) |
10 | 3 | 0.1 | H2O | 24 | 25 | 76 (R) |
11 | 3 | 0.05 | H2O | 48 | 26 | 81 (R) |
12 | 3 | 0.1 | DMSO | 48 | 11 | 68 (R) |
13 | 4 | 0.3 | H2O | 24 | 36 | 83 (S) |
14 | 4 | 0.1 | H2O | 24 | 22 | 79 (S) |
15 | 4 | 0.05 | H2O | 48 | 24 | 75 (S) |
16 | 4 | 0.1 | DMSO | 48 | 12 | 61 (S) |