Entry

Catalyst

Amount of catalyst (equiv)

Solvent

Time (h)

Yield (%)

ee^a (%)

1

1

0.3

H₂O

0.5

98

86 (R)

2

1

0.1

H₂O

0.5

90

89 (R)

3

1

0.05

H₂O

2

82

89 (R)

4

1

0.1

DMSO

48

11

19 (R)

5

2

0.3

H₂O

0.5

98

89 (S)

6

2

0.1

H₂O

0.5

89

91 (S)

7

2

0.05

H₂O

2

81

87 (S)

8

2

0.1

DMSO

48

23

31 (S)

9

3

0.3

H₂O

24

32

83 (R)

10

3

0.1

H₂O

24

25

76 (R)

11

3

0.05

H₂O

48

26

81 (R)

12

3

0.1

DMSO

48

11

68 (R)

13

4

0.3

H₂O

24

36

83 (S)

14

4

0.1

H₂O

24

22

79 (S)

15

4

0.05

H₂O

48

24

75 (S)

16

4

0.1

DMSO

48

12

61 (S)