Treatments and Dose (mg/kg) | ||||||||||
| Distilled water (10 mL/kg) | ASA (100) | Morphine (2 mL/kg) | BPA | BPE | |||||
200 | 400 | 800 | 200 | 400 | 800 | |||||
MTRT (sec) ± SEM | Zero min (T0) | 3.44 ± 0.24 | 3.22 ± 0.26* | 3.34 ± 0.12 | 3.34 ± 0.26* | 3.32 ± 0.26* | 3.50 ± 0.14 | 1.39 ± 0.14 | 1.38 ± 0.13 | 1.40 ± 0.13 |
30 mins (T1) | 3.66 ± 0.28 | 3.84 ± 0.34 | 4.80 ± 0.03* | 3.38 ± 0.28 | 3.68 ± 0.11 | 3.64 ± 0.30 | 1.47 ± 0.09 | 1.40 ± 0.18 | 1.64 ± 0.13 | |
60 mins (T2) | 3.56 ± 0.28 | 3.86 ± 0.29 | 4.70 ± 0.07* | 3.50 ± 0.20 | 3.52 ± 0.11 | 3.54 ± 0.14 | 1.40 ± 0.08 | 1.49 ± 0.16 | 1.41 ± 0.16 | |
T1-T0 | 0.22 ± 0.37 | 0.62 ± 0.14 | 1.46 ± 0.11* | 0.04 ± 0.13 | 0.36 ± 0.23 | 0.14 ± 0.31 | 0.08 ± 0.14 | 0.02 ± 0.25 | 0.24 ± 0.12 | |
T2-T0 | 0.12 ± 0.37 | 0.64 ± 0.31 | 1.36 ± 0.16* | 0.16 ± 0.14 | 0.20 ± 0.21 | 0.04 ± 0.16 | 0.01 ± 0.13 | 0.01 ± 0.14 | 0.01 ± 0.14 | |
PI (%) | T1 (0 min = reference) | - | 19.3 | 30.4 | 1.2 | 1.1 | 2.9 | 5.8 | 1.5 | 17.1 |
T2 (0 min = reference) | - | 19.9 | 28.9 | 4.8 | 6.0 | 1.2 | 0.7 | 8.0 | 0.7 | |
T1 (DW = reference) | - | 4.9 | 23.6 | - | 0.6 | - | - | - | 7.9 | |
T2 (DW) = reference | - | 8.4 | 24.3 | - | - | - | - | - | - |