Time

(months)

Sample

Drug content (%)

(n = 3)

Percent of LPZ release (n = 6)

Y1

Y2

t = 0

B1

102.93 ± 1.02

3.09 ± 0.48

96.94 ± 1.96

B2

102.45 ± 1.27

3.49 ± 0.20

98.92 ± 1.70

B3

101.98 ± 2.11

3.39 ± 0.07

97.26 ± 1.63

t = 3

B1

rc

101.84 ± 0.61

2.91 ± 0.46

96.41 ± 1.85

B1

ac

101.29 ± 1.32

3.10 ± 0.30

98.68 ± 1.60

B2

rc

100.09 ± 0.29

3.08 ± 0.24

98.93 ± 1.62

B2

ac

100.99 ± 1.76

3.64 ± 0.40

99.59 ± 1.27

B3

rc

101.60 ± 2.63

3.07 ± 0.22

99.66 ± 2.18

B3

ac

101.69 ± 1.03

3.57 ± 0.39

99.42 ± 1.35

t = 6

B1

rc

101.50 ± 1.09

2.98 ± 0.38

96.00 ± 1.26

B1

ac

99.52 ± 1.18

3.67 ± 0.28

98.58 ± 1.19

B2

rc

99.93 ± 0.52

3.45 ± 0.23

98.08 ± 1.26

B2

ac

101.96 ± 0.10

3.92 ± 0.24

98.84 ± 1.88

B3

rc

101.94 ± 2.53

3.43 ± 0.12

98.54 ± 1.92

B3

ac

99.48 ± 1.09

3.75 ± 0.43

98.62 ± 0.78

t=12

B1

rc

102.21 ± 0.81

3.31 ± 0.27

98.85 ± 1.15

B2

rc

101.93 ± 1.03

3.38 ± 0.34

99.33 ± 1.14

B3

rc

99.77 ± 1.82

3.35 ± 0.28

98.92 ± 0.89

t = 18

B1

rc

100.32 ± 0.93

4.08 ± 0.21

94.72 ± 1.32

B2

rc

100.75 ± 1.25

4.96 ± 0.38

93.63 ± 1.59

B3

rc

99.25 ± 1.08

4.18 ± 0.58

95.85 ± 1.36