(a) Morphine

Parameter

Vehicle

Diclofenac

Tmax (min)

15.0 ± 0002

15.0 ± 0.002

Cmax (μg/ml)

3.90 ± 0.180

7.2 ± 0.189*

AUC (mg/ml∙min)

0.132 ± 0.0368

0.282 ± 0.0247*

t1/2 (min)

22.0 ± 0.472

21.0 ± 0.389

Vd (L/kg)

2.70 ± 0.970

1.40 ± 0.337*

CLtot (L/hr/kg)

0.033 ± 0.00953

0.018 ± 0.00152*