Target specie(s)

Disease(s) and/or bacterial agent(s)

Type of infection

Regimen of enrofloxacin

Purpose of the study

Number of animals

Result(s)

References

CATTLE

Dairy

cows

Acute clinical mastitis (Escherichia coli)

N

5 mg/kg IV then SC 24 h later

Comparative efficacy of a ENR + KET treatment and a KET treatment

132 (64 ENR + KET, no controls)

Inefficacy of ENR to treat acute clinical E. coli mastitis

[118]

Sahiwal cattle

Anaplasma marginale

N

5 mg/kg IV SID for 5 days

Comparative efficacy of ENR, OXY and IMI

60 (15 per group + 15 controls)

Inefficacy of ENR to clear persistent infection

[119]

Holstein calves

Anaplasma marginale

E

7.5 mg/kg in a single dose or twice every 3 days

Comparative efficacy of ENR (2 regimens) and LA-OXY

24 (6 per group + 6 controls)

Superiority of ENR

[120]

Calves

Pneumonic pasteurellosis (Pasteurella haemolytica A1)

E

2.5 mg/kg SC SID for 3 days

Efficacy of ENR

36 (12 ENR + 12 positive controls + 12 negative controls)

Inefficacy of ENR to treat experimentally induced pneumonic pasteurellosis

[121]

Feeder calves

Bovine respiratory disease (Mh, Pam, Hs, Mb)

N

12.5 mg/kg SC in a single injection

Comparative efficacy of ENR and TUL in two different states of USA

500 (125 per group per site)

Superiority of TUL

[122]

POULTRY

Chickens

Escherichia coli (Ec) and Pasteurella multocida (Pam)

E

10 mg/kg BID in drinking water for 5 days

Efficacy of ENR (given immediately or 6 hours after infection)

Ec: 30 (10 per group + 10 controls) Pam: 20 (7 per group + 6 controls)

Efficacy of ENR against Ec and Pam

[123]

Broilers

Mycoplasma gallisepticum (Mg)

N

5 mg/kg in drinking water at 1 - 10 and 22 - 32 days of age

Efficacy of ENR in a treatment program against Mg in offspring of Mg-infected chicken-broiler breeders

45,000 (22,500 ENR + 22,500 controls)

Efficacy of ENR

[124]

Chicks (White Leghorn)

Salmonella enterica Serovar Typhimurium DT104

E

10 mg/kg for 5 days (1) or 25 mg/kg for 2 days (2) or 50 mg/kg for 1 day (3) (continuously or pulsed in water or gavage)

Efficacy of ENR (comparative efficacy of high dose short duration treatments and conventional treatment)

481 (151 in (1) + 141 in (2) + 89 in (3) + 100 controls)

Efficacy and best compromise for the 2-day 2.5 dosing treatment

[125]

Broilers (male chicks)

Colibacillosis (Escherichia coli)

E

50 ppm in drinking water for 7 days

Comparative efficacy of ENR and bacteriophage (individually and in combination)

320 (40 for each one of the 8 treatments)

Superiority of ENR but synergy between ENR and bacteriophage

[126]

Turkeys (poults)

Respiratory infections due to Ornithobacterium rhinotracheale (associated with avian metapneumovirus)

E

10 mg/kg in drinking water during 20 hours for 5 days or 50 mg/kg during 5, 10 or 20 hours in a single day

Efficacy of ENR (comparative efficacy of 4 regimens)

80 (16 per group + 16 controls)

Superiority of the 10 mg/kg 5-day ENR treatment

[127]