Virus

Genes and Proteins Involved in Cancer

Cancer

Treatment Available for Virus Infection

EBV

LMP1, LMP2A, AKT, NF-kB, NOTCH, and phosphatidylinositol 3 kinase

Hodgkin Lymphoma, Burkitt Lymphoma, Diffuse Large B Cell Lymphoma, Pyrothorax Lymphoma, Nasopharyngeal Carcinoma, Gastric Carcinoma, and Leiomyosarcoma

No specific antiviral treatment

HBV/HCV

TP53, CTNNB1, AXIN, ARID1A, AXIN1, and CDKN2A, and ARID1A

Hepatocellular carcinoma

Pegylated interferon, ribavirin, boceprevir, and telaprevir

HHV-6

ORF-1, p53, U95, NF-kB

Oral Squamous Cell Carcinoma, Hodgkin’s Disease, non-Hodgkin’s lymphoma, and cervical carcinoma

No specific antiviral treatment; immunotherapy

HHV-8

K1, vIRF, and cIL8R

Karposi’s Sarcoma and Primary Effusion Lymphoma

Ganciclovir and Foscarnet

HPV

E5, E6, and E7

Cervical Cancer

Vitamin A and curcumin

HTLV-1

p53

Adult T-Cell Leukemia/Lymphoma

Corticosteroids, Plasmapheresis, Cyclophosphamide, Interferon, Valproic Acid, and Zidovudine

MCPyV

CD3G, CD3D, ZAP70, and IGHM

Merkel Cell Carcinomas

Nospecific antiviral treatment