Aripiprazole

Cariprazine

Mania

Mania

Keck et al. (2009); TGA (2009)

McIntyre et al. (2009)

Plac. alone

Lith. alone

Arip. alone

Plac. alone

Carip.

(3 - 12 mg/day)

alone

YMRS

n = 163

n = 154

n = 153

YMRS

n = 172

n = 281

Baseline

48

49

48

Baseline

54

53

3-wk end

33

29

26

3-wk end

37

27

3-wk change

(−15)

(−20)

(−22)

3-wk change

(−17)

(−26)

Placebo (%)

–

75

68

Placebo (%)

–

65

Absolute

Advantage (%)

–

+5

+7

Absolute advantage (%)

–

+9

Depression

Depression

Fava et al. (2012)

Earley et al. (2019)

Plac. + antidep.

Arip. + antidep.

Plac. alone

Carip.

(1.5 mg/day) alone

Carip.

(3.0 mg/day) alone

MADRS

N = 54

N = 167

MADRS

N = 141

N = 145

N = 164

Baseline

52

51

Baseline

50

51

52

4-wk end

39

37

6-wk end

29

26

26

4-wk change

(−13)

(−14)

6-wk change

(−21)

(−25)

(−26)

Placebo (%)

–

93

Placebo (%)

–

84

81

Absolute advantage (%)

–

+1

Absolute advantage (%)

–

+4

+5