Term | Description | Genes | FDR | |
Biological processes | ||||
GO:0055114 | Oxidation-reduction process | ME1, HSD3B3, ACADSB, NDUFB5, NDUFB6, CYP3A25, EHHADH, CYP2B9, PAH, UQCRFS1, ALDH3A2, BBOX1, FMO3, HSD17B6, CAT, CYP2C54, CYP3A16, CYP3A11, CYP2C29, IDO2, FADS2, CYP1A2, CYP2C50, CYP4A10, HAO2, CYP8B1 | 2.60E−17 | |
GO:0008152 | Metabolic process | HSD3B3, ACADSB, EHHADH, ECHDC1, PAH, ACSS3, ALDH3A2, AFMID, GSTM1, AADAC, TYMP, ACSL1, PYGL, PKLR, AACS, ACAA1B, UGP2 | 1.89E−09 | |
GO:0006629 | Lipid metabolic process | HACL1, ACADSB, ACSL1, SULT2A1, EHHADH, APOC3, HSD17B6, FADS2, CYP1A2, AACS, ACAA1B, THRSP | 3.76E−04 | |
GO:0006631 | Fatty acid metabolic process | CYP4A10, ACADSB, APOA2, ACSL1, EHHADH, FADS2, AACS, ACAA1B | 0.0011 | |
GO:0019373 | Epoxygenase P450 pathway | CYP2A22, CYP2C54, CYP2B9, CYP2C29, CYP2C50 | 0.003784 | |
GO:0042493 | Response to drug | APOA2, ACSL1, ABCB11, ABAT, ABCD3, CAT, UQCRFS1, AACS | 0.169252 | |
GO:0006810 | Transport | TTR, NDUFB5, APOA2, NDUFB6, ABCB11, SLC2A2, APOC3, ABCA8A, ABCD3, FADS2, UQCRFS1, ATP5J | 38.61568 | |
Cellular component | ||||
GO:0031090 | Organelle membrane | CYP4A10, AADAC, CYP2C54, CYP3A16, CYP3A25, CYP3A11, CYP2B9, FMO3, CYP2C29, CYP1A2, CYP8B1, CYP2C50 | 1.00E−11 | |
GO:0005739 | Mitochondrion | ME1, ETNPPL, HSD3B3, FKBP8, ACADSB, NDUFB5, NDUFB6, EHHADH, UQCRFS1, AGXT, ACSS3, ALDH3A2, BBOX1, GLS2, ACSL1, ABCD3, GCSH, CAT, ACAA1B, ATP5J, LACTB2, GM4952, GCK, HAO2, ABAT, OAT | 4.24E−08 | |
GO:0005789 | Endoplasmic reticulum membrane | REEP6, HSD3B3, CYP2C54, CYP3A25, CYP3A16, CYP3A11, CYP2B9, CYP2C29, FADS2, CYP1A2, ALDH3A2, CYP2C50, AADAC, CYP4A10, ACSL1, FMO3, CYP8B1 | 6.94E−07 | |
GO:0043231 | Intracellular membrane-bounded organelle | CYP2C54, CYP3A25, CYP3A16, CYP3A11, CYP2B9, CYP2C29, CYP1A2, ALDH3A2, CYP2C50, AADAC, CYP4A10, ACSL1, FMO3, ABCD3, HSD17B6, CAT, CYP8B1 | 1.56E−06 | |
GO:0005783 | Endoplasmic reticulum | REEP6, HSD3B3, CYP2C54, CYP3A25, CYP3A16, CYP2B9, CYP3A11, CYP2C29, FADS2, CYP1A2, ALDH3A2, CYP2C50, AADAC, CYP4A10, ACSL1, FMO3, HSD17B6, CAT, CES1E, CYP8B1, CES1C | 3.58E−06 | |
GO:0005777 | Peroxisome | HACL1, ACSL1, EHHADH, HAO2, ABCD3, CAT, ACAA1B, AGXT | 2.27E−04 | |
GO:0005829 | Cytosol | ME1, SULT2A5, SULT2A1, EHHADH, ECHDC1, ALDH3A2, INMT, AFMID, TYMP, APOA2, GCK, SLC2A2, APOC3, PKLR, CAT, AACS, THRSP | 0.145049 | |
GO:0005743 | Mitochondrial inner membrane | HSD3B3, NDUFB5, NDUFB6, ABCA8A, ABCD3, UQCRFS1, ALDH3A2, ATP5J | 0.259456 | |
GO:0005759 | Mitochondrial matrix | GLS2, ACADSB, ABAT, OAT, AGXT, LACTB2 | 0.369843 | |
GO:0070062 | Extracellular exosome | ACADSB, ABCB11, ECHDC1, PAH, ALDH3A2, BBOX1, CYP4A10, TTR, APOA2, PYGL, APOC3, PKLR, HAO2, ABAT, CAT, UGP2 | 20.70699 | |
Molecular function | ||||
GO:0016491 | Oxidoreductase activity | ME1, HSD3B3, ACADSB, CYP2C54, CYP3A25, CYP3A16, CYP2B9, EHHADH, CYP3A11, CYP2C29, IDO2, FADS2, PAH, CYP1A2, UQCRFS1, ALDH3A2, BBOX1, CYP2C50, CYP4A10, HAO2, FMO3, HSD17B6, CAT, CYP8B1 | 5.09E−15 | |
GO:0004497 | Monooxygenase activity | CYP4A10, CYP2C54, CYP3A16, CYP3A25, CYP3A11, CYP2B9, FMO3, CYP2C29, PAH, CYP1A2, CYP8B1, CYP2C50 | 1.79E−10 | |
GO:0020037 | Heme binding | CYP3A25, CYP3A16, CYP2C54, CYP3A11, CYP2B9, CYP2C29, IDO2, CYP1A2, CYP2C50, CYP4A10, CYP2A22, CAT, CYP8B1 | 1.52E−09 | |
GO:0005506 | Iron ion binding | CYP3A25, CYP3A16, CYP2C54, CYP3A11, CYP2B9, CYP2C29, PAH, CYP1A2, BBOX1, CYP2C50, CYP4A10, CYP2A22, CYP8B1 | 1.47E−08 | |
GO:0070330 | Aromatase activity | CYP2C54, CYP3A16, CYP3A25, CYP3A11, CYP2B9, CYP2C29, CYP1A2, CYP2C50 | 5.45E−08 | |
GO:0016705 | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP4A10, CYP2C54, CYP3A16, CYP3A25, CYP3A11, CYP2B9, CYP2C29, CYP1A2, CYP8B1, CYP2C50 | 9.66E−08 | |
GO:0003824 | Catalytic activity | ETNPPL, HACL1, HSD3B3, EHHADH, ECHDC1, PAH, ACSS3, AGXT, ACSL1, PYGL, PKLR, HAO2, ABAT, AACS, OAT, ACAA1B | 1.39E−07 | |
GO:0016712 | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP2A22, CYP3A16, CYP3A25, CYP3A11, CYP2B9, CYP2C29, CYP1A2 | 1.03E−05 | |
GO:0008392 | Arachidonic acid epoxygenase activity | CYP4A10, CYP2A22, CYP2C54, CYP2B9, CYP2C29, CYP2C50 | 8.90E−04 | |
GO:0008395 | Steroid hydroxylase activity | CYP2A22, CYP2C54, CYP2B9, CYP2C29, CYP2C50 | 0.053216 | |
GO:0030170 | Pyridoxal phosphate binding | ETNPPL, PYGL, ABAT, OAT, AGXT | 0.057234 | |
GO:0016740 | Transferase activity | SULT2A5, ETNPPL, SULT2A1, AGXT, INMT, GSTM1, GM4952, TYMP, GCK, PYGL, PKLR, ABAT, OAT, ACAA1B, UGP2 | 0.788706 | |
GO:0042803 | Protein homodimerization activity | GSTM1, APOA2, PYGL, ABAT, ABCD3, PAH, CAT, AGXT, THRSP | 9.244787 | |
GO:0046872 | Metal ion binding | ME1, HACL1, CYP2C54, CYP3A25, CYP3A16, CYP3A11, CYP2B9, CYP2C29, IDO2, PAH, CYPF2, UQCRFS1, LACTB2, BBOX1, CYP2C50, CYP4A10, PKLR, ABAT, CAT, CYP8B1, UGP2 | 14.20634 | |
GO:0042802 | Identical protein binding | ETNPPL, TTR, HACL1, FKBP8, ABAT, OAT, UGP2 | 27.05591 | |