Author, year

N

Inclusion criteria age range (yrs)

Mean age (yrs)

CB group

Mean age (yrs)

PB group

Mean weight (kg)

CB group

Mean weight (kg)

PB group

Medication dose CB group

Medication dose PB group

Time to 1^st additive analgesia (min)

CB group

(mean ± SD)

Time to 1^st additive analgesia (min) PB group

(mean ± SD)

F/U (hrs)

Yeoman et al., 1983

38

1.5 to 12

6.25 ± 3.2

6.5 ± 3.2

22.3

23.2

0.5% bupivacaine (1 mL/yr + 2 mL)

0.5% bupivacaine

(1 mL/3yr)

-

-

7

Vater & Wandless, 1985

50

1 to 13

5.6 ± 3.4

4.6 ± 2.9

20.3 ± 7.3

18.1 ± 6.2

0.25% bupivacaine

(0.5 mL/kg)

0.5% bupivacaine

(1-5 yrs - 3 mL; 6-12 yrs - 4 mL)

313 ± 183.3

256.4 ± 177.6

24

Irwin & Chang, 1996

50

2 to 12

5.1 ± 2.1

6.4 ± 2.9

18.9 ± 5.9

22.3 ± 9.4

0.25% bupivacaine

(0.75 mL/kg)

0.5% bupivacaine

(1-2 mL)

-

-

24

Mak et al., 2001

126

1 to 12

6.5 ± 2.9

6.5 ± 3.0

24.6 ± 9.4

23.3 ± 8.0

0.25% bupivacaine

(0.5 mL/kg)

0.5% bupivacaine

(<15 kg - 2 mL; 15 - 24 kg - 2.5 mL; 25 - 30 kg - 3 mL; 31 - 40 kg - 3.5 mL; >40 kg - 4 mL)

354 ± 143.8

366 ± 173.2

96

Gautlett, 2003

60

1 to 10

5.09 ± 2.32

5.47 ± 2.43

20.9 ± 6.0

22.1 ± 6.9

0.15% bupivacaine (0.5 mL/kg), ketamine (0.5 mg/kg)

0.5% bupivacaine

(3 - 5 mL by age + 1 mL subQ)

-

-

24

Weksler et al., 2005

100

3 to 8

5 ± 2

5 ± 2

20 ± 4

20 ± 4

0.25% bupivacaine

(1 mL/kg)

0.5% bupivacaine

(0.3 mL/kg)

-

-

24

Margetts et al., 2008

40

1.5 to 16

7.8 ± 1.7

7.9 ± 1.3

-

-

0.25% bupivacaine (0.5 mL/kg), ketamine (0.5 mg/kg)

0.5% bupivacaine

(0.25 mL/kg)

485.8 ± 124.9

361.3 ± 183.1

24

Beyaz, 2011

50

3 to 12

7.4 ± 3.1

8.5 ± 3.5

23.4 ± 8.6

29.4 ±11.3

0.25% levo-bupivacaine

(0.5 mL/kg)

0.25% levo-bupivacaine

(0.5 mL/kg)

354 ± 15

352 ± 18

6

Kazak et al., 2012

60

2 to 10

6 ± 3

7 ± 2

23 ± 9

26 ± 6

0.25% levo-bupivacaine

(1 mg/kg)

0.25% levo-bupivacaine

(1 mg/kg)

458 ± 73

376 ± 68

24