Variable | Total n, (%) | Low malignant potential (Benign) n = 15 (65.2) | High malignant potential (Malignant) n = 8 (34.8) | p-value* |
Age at diagnosis, years) (mean, SD) | 23 | 12 62.6 (12.6) | 8 65.5 (9.4) |
0.58 |
Gender | 23 |
|
|
|
Male Female | 6 (26.1) 17 (73.9) | 3 (20) 12 (80) | 3 (37.5) 5 (62.5) | 0.334 |
Symptoms at diagnosis | 23 |
|
|
|
Symptomatic Asymptomatic | 11 (47.8) 12 (52.2) | 6 (40) 9 (60) | 5 (62.5) 3 (37.5) | 0.28 |
Tumor diameter, cm (mean, SD, range) | 21 9.1 (7.3, 1.2 - 27) | 13 6.9 (5.3, 1.5 - 16) | 8 12.8 (8.8, 1.2 - 27) |
0.070 |
Tumor diametersubgroup | 21 |
|
|
|
<5 cm >5 cm | 8 (38.1) 13 (61.9) | 7 (53.9) 6 (46.2) | 1 (12.5) 7 (87.5) | 0.074 |
Tumor base | 22 |
|
|
|
Sessile/Inverted Pedunculated | 7 (31.8) 15 (68.2) | 4 (28.6) 10 (71.4) | 3 (37.5) 5 (62.5) | 0.51 |
Mitoses/10 HPF | 21 |
|
|
|
<4/10 HPF >4/10 HPF | 16 (76.2) 5 (23.8) | 13 (100) 0 | 3 (37.5) 5 (62.5) | 0.003 |
Tumor necrosis | 19 |
|
|
|
Absent Present | 11 (57.9) 8 (42.1) | 10 (90.9) 1 (9.1) | 1 (12.5) 7 (87.5) | 0.001 |
Tumor hemorrhage | 18 |
|
|
|
Absent Present | 11 (61.1) 7 (38.9) | 7 (63.6) 4 (36.4) | 4 (57.1) 3 (42.9) | 0.58 |
Nuclear Crowding/overlap | 17 |
|
|
|
Absent Present | 14 (82.4) 3 (17.7) | 13 (100) 0 | 1 (25) 3 (75) | 0.006 |
Infiltration of adjacent structures | 21 |
|
|
|
Absent Present | 18 (85.7) 3 (14.3) | 13 (100) 0 | 5 (62.5) 3 (37.5) | 0.042 |
Stromal Invasion | 4 |
|
|
|
Absent Present | 4 (80) 1 (20) | 1 (100) 0 | 3 (75) 1 (25) | 0.80 |
Vascular Invasion | 5 |
|
|
|
Absent Present | 4 (80) 1 (20) | 1 (100) 0 | 3 (75) 1 (25) | 0.80 |
Encapsulation | 20 |
|
|
|
Absent Present | 1 (5) 19 (95) | 0 13 (100) | 1 (14.3) 6 (85.7) | 0.350 |
Tumor contour | 22 |
|
|
|
Lobulated Smooth | 12 (54.6) 10 (45.5) | 6 (42.9) 8 (57.1) | 6 (75) 2 (25) | 0.156 |
Tumor border with adjacent structures | 23 |
|
|
|
Poorly defined Well defined | 1 22 | 0 15 (100) | 1 (12.5) 7 (87.5) | 0.348 |
Pleural pattern | 23 |
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|
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Visceral Parietal | 20 (87) 3 (13) | 13 (86.7) 2 (13.3) | 7 (87.5) 8 (100) | 0.73 |