Variables | Absolute change in Physician Global VAS 24 weeks after treatment (n = 177) | Absolute change in Muscle Disease Activity VAS 24 weeks after treatment (n = 177) | Absolute change in Extramuscular Global VAS 24 weeks after treatment (n = 177) | |||
| Correlation Coefficient | P-value | Correlation Coefficient | P-value | Correlation Coefficient | P-value |
Demographic features |
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Age at diagnosis, years | −0.03 | 0.71 | −0.07 | 0.35 | 0.01 | 0.94 |
Time to diagnosis, years | 0.09 | 0.21 | 0.04 | 0.54 | −0.01 | 0.85 |
Male sex | 1.23 | 0.27 | 0.04 | 0.84 | 0.33 | 0.57 |
Race, Caucasian | 0.56 | 0.45 | 2.40 | 0.12 | 0.29 | 0.59 |
Disease subset, juvenile DM | 0.19 | 0.67 | 0.06 | 0.81 | <0.01 | 0.99 |
Disease subset, adult DM | 0.35 | 0.55 | 0.89 | 0.35 | 1.92 | 0.17 |
Medication |
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Prednisone use | 0.29 | 0.59 | 0.71 | 0.40 | 1.73 | 0.19 |
DMARD use | 1.22 | 0.27 | 0.48 | 0.49 | 1.03 | 0.31 |
Number of failed immunosuppressive agents | 0.02 | 0.82 | 0.02 | 0.79 | −0.11 | 0.15 |
Clinical parameters |
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Physician’s Global Assessment VAS | −0.40 | <0.01 | −0.37 | <0.01 | −0.21 | <0.01 |
Muscle Disease Activity VAS | −0.28 | <0.01 | −0.42 | <0.01 | −0.16 | 0.03 |
Extramuscular Global Assessment VAS | −0.24 | <0.01 | −0.21 | <0.01 | −0.57 | <0.01 |
Constitutional Disease Activity VAS | −0.16 | 0.03 | −0.14 | 0.06 | −0.34 | <0.01 |
Cutaneous Disease Activity VAS | −0.19 | 0.01 | −0.13 | 0.08 | −0.29 | <0.01 |
Skeletal Disease Activity VAS | −0.06 | 0.41 | −0.05 | 0.51 | −0.13 | 0.08 |
Pulmonary Disease Activity VAS | 0.01 | 0.93 | 0.07 | 0.36 | −0.12 | 0.11 |
Patient’s/parent’s Global Assessment VAS | −0.16 | 0.03 | −0.09 | 0.20 | −0.12 | 0.09 |
Manual Muscle Testing (MMT8) | 0.08 | 0.29 | 0.10 | 0.19 | 0.11 | 0.15 |
HAQ/C-HAQ Disability Index | −0.05 | 0.49 | −0.09 | 0.20 | −0.16 | 0.03 |
Overall Damage Score | −0.02 | 0.77 | −0.02 | 0.74 | −0.06 | 0.42 |
Laboratory parameters |
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Lymphocyte count | 0.21 | <0.01 | 0.17 | 0.02 | 0.11 | 0.13 |
ALT | −0.08 | 0.29 | −0.05 | 0.46 | −0.01 | 0.85 |
AST | −0.21 | <0.01 | −0.15 | 0.04 | −0.16 | 0.03 |
Aldolase | −0.10 | 0.20 | −0.09 | 0.24 | −0.03 | 0.72 |
CPK | −0.07 | 0.33 | −0.06 | 0.46 | <0.01 | 0.97 |
Total IgG | −0.11 | 0.13 | −0.06 | 0.39 | −0.11 | 0.12 |
Total IgM | −0.10 | 0.18 | −0.11 | 0.14 | −0.17 | 0.02 |
Autoantibody groups |
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