Souza et al. 2016 [12] | RCT NCT01975694 | 45 women with HSDD Average age: 53 | Tribulus terrestrisc 750 mg/day (n = 20) Placebo (n = 16) 12 weeks | Primary: efficacy of HSDD Secondary: testosterone | Improvements in total FSFI score and most domains, increase of free and bioavailable testosterone NO differences respecting placebo |
Vale et al. 2018 [14] | RCT NCT01971099 | 40 women with HSDD Age: 18 - 44 | Tribulus terrestrisc, 750 mg/day (n = 20) Placebo (n = 20) 120 days | Primary: efficacy of HSDD Secondary: testosterone | Improvements in total FSFI score and most domains, increase of free and bioavailable testosterone NO differences respecting placebo |
Bernorio et al. 2018 [15] | RCT Pilot study | 60 women with FSD Age: 18 - 60 | Visnadine spray (n = 30) Placebo (n = 30) 30 days | Efficacy on FSD | Improvements in sexual function (FSFI) in women with/without FSD respect to placebo (p < 0.05) |
Caruso et al. 2018 [21] | RCT crossover study | 38 women with HSDD Age: 25 - 40 | Visnadine spray on demand (n = 30) Visnadine spray daily (n = 30) 60 days | Efficacy on HSDD | Both improved HSDD (p < 0.001) |
Caputo et al. 2018 [21] | RCT pilot study | 69 women with FSD Average Age: 35 - 38 | Visnadine oil (n = 30) Placebo (n = 30) 8 weeks | Efficacy on FSD | Improvements on FSFI (p < 0.05) |
Meston et al. 2008 [16] | RCT | 63 women with FSD + 36 with DFSD (antidepressant) Age: 18 - 65. | Ginkgo bilobaf 300 mg/day (n = 19) Ginkgo biloba + sex therapy (n = 14) Sex therapy (n = 19) Placebo (n = 16 ) 8 weeks | Efficacy on DIFSD | Ginkgo biloba + sex therapy increased desire respect placebo (p < 0.05), but not Ginkgo biloba alone Sex therapy alone enhanced orgasm function respect placebo (p < 0.05). |
Kashani et al. 2013 [17] | RCT 138711121556N3 | 38 women with DFSD (fluoxetine) Age:18 - 45 | Saffrong 30 mg/day (n = 19) Placebo (n = 19) 4 weeks | Efficacy on DIFSD | Improvement in total FSFI (p < 0.001), arousal (p = 0.028), lubrication (p = 0.035), and pain (p = 0.016) but not in desire, satisfaction and orgasm. |
Farnia et al. 2015 [18] | RCT IRCT2013100114333N9 | 61 women with DFSD (SSRI) Age: 34 | Rosa damascena oilh 2 ml/day (n = 31) Placebo (n = 31) 8 weeks | Efficacy on DIFSD | No Improvements on FSFI compared to placebo |
Farnia et al. 2017 [19] | RCT IRCT2015091523705N2 | 50 women with DFSD (methadone) Age: 38.8 | Rosa damascena oilh 2 ml/day (n = 25) Placebo (n = 25) 8 weeks | Efficacy on DIFSD Sex hormones | Improvements on FSFI (p < 0.05) and sex hormones compared to placebo |