Onset age of lipodystrophy

Distribution of adipose tissue

Clinical and biological parameters

Genetic

Generalized

BSCL1 BSCL2

BSCL3

Childbirth or early childhood

Complete lipoatrophy

Acanthosis nigricans

Dyslipidemia

Diabetes

Partial

FPLD2

Puberty

Lipoatrophy of the limbs and buttocks, increase of fat in the face and neck

Metabolic laminopathy

Puberty

Light lipodystrophy or absent

FPLD3

Puberty

Lower body lipoatrophy

Hypertension

Acanthosis nigricans

Dyslipidemia

Diabetes

AKT2-linked

Partial lipodystrophy

Hypertension

Acanthosis nigricans

Diabetes

Acquired

Generalized

Lawrence Syndrome

Childhood or adulthood

Complete lipoatrophy

Sometimes panniculitis,

Acanthosis nigricans

Dyslipidemia

Diabetes

Partial

Barraquer-Simmons Syndrome

Adolescence or beginning of adulthood

Lipoatrophy in upper part of the body

Lower body fat accumulation

Infrequent metabolic alterations

Sometimes low C3 and membranoproliferative glomerulonephritis

Hypercortisolism-related

Usually adulthood

Lower lipoatrophy

Fat accumulation in the upper part of the body

Dyslipidemia

Frequently with diabetes

Generalized or Partial

HIV-related

Usually adulthood

Peripheral lipoatrophy

Central lipoatrophy or fat accumulation

Dyslipidemia

Sometimes diabetes