Case 1

Case 2

Case 3

Multinuclear giant cells

Observed

Observed

Observed

Xhantomatous cells

Observed

Observed

Observed

Granular body

Observed

Observed

Observed

Rosenthal fibers

Observed

Observed

Observed

Nuclear inclusions

Not observed

Not observed

Observed

Increased reticular fibers

Observed

Observed (mild)

Observed

Perivasculary lymphocytes

Observed

Observed

Observed

Calcifications

Observed

Not observed

Not observed

Mitosis/10 HPF

5 - 6

5

6

Endothelial proliferation

Observed

Not observed

Observed

Necrosis

Not observed (2)

Not observed

Observed

Ki-67 proliferation index

80%

20%

20%

GFAP

Positive

Positive

Positive (focal)

MAP-2

Positive

Negative

Negative

Synaptophysin/Neu-N/chromogranin

Negative

Negative

Negative

CD-34

Negative

Negative

Negative

p-53

40%

Negative

10%

BRAF mutation (V600E)

Observed

Not observed

Observed

P16 mutation

Not observed

Technical problem

Observed