Case

Age (yr)/

Sex

Diagnosis

Presentation

Medications before Symptoms/ Cause of Fever

APACHE II

Score

Temp (Max)

(˚F)

Time to Resolution of Symptoms

Dantrolene Bolus (mg)/ (mg/kg)

Outcome

1

M/44

NMS

Altered Consciousness

Haloperidol, Metoclopramide

16

102.5

5

250/(2.5)

R

2

M/41

NMS

Altered Consciousness

Haloperidol, Ziprasidone

12

101.4

11

235/(1.5)

R

3

M/39

NMS

Involuntary Movements

Quetiapine

10

102

9

100/(2)

R

4

M/56

NMS

Altered Consciousness

Escitalopram, Topiramate, Biperiden, Clozapine

22

101.1

14

58/(1)

R

5

F/63

NMS

Altered Consciousness

Quetiapine

13

101.3

17

75/(1)

R

6

M/56

NMS

Altered Consciousness

Risperidone,

19

103

9

100/(1.5)

R

7

M/67

NMS

Altered Consciousness

Levetiracetam, Clonazepam

21

102

10

250/(2)

R

8

M/39

NMS

Altered Consciousness

Ziprasidone, Haloperidol

13

100.3

8

375/(2.5)

R

9

M/65

NMS

Hyperthermia, Agitation

Citalopram, Quetiapine, Haloperidol

20

102

11

375/(2.5)

R

10

M/32

MH

Hyperthermia/Acidosis

Desflurane

15

101.1

2

345/(3)

R

11

F/55

MH

Hyperthermia/Acidosis

Sevoflurane

17

102.4

3

355/(2.5)

R

12

M/39

Sepsis

Abdominal Pain

Klebsiella puemoniae

26

104

12

480/(2)

D

13

F/61

sepsis

Fever/Perforated Bowel

Escherichia coli

34

104

58

400/(2.5)

R

14

F/51

Sepsis

Intracranial Hemorrhage

Staphylococcus aureus

31

104.3

21

225/(3)

R

15

M/52

Sepsis

Pneumonia

Streptococcus puemoniae

30

101.6

17

235/(2.5)

R

16

F/82

Sepsis

Staphylococcal Infection

Staphylococcus aureus

36

102

9

100/(2.0)

D

17

M/19

Sepsis

Convulsions/Pneumonia

Streptococcus pyogenes

35

101.6

29

160/(1.8)

R

18

M/39

Sepsis

Aortic Dissection

Staphylococcus aureus

46

104

5

200/(2.5)

D

19

F/11

Sepsis

Septic Shock

Escherichia coli

49

102

11

85/(1.0)

D

20

M/67

NMS/S

Altered Mental Status

Staphylococcus aureus/Ziprasidone

55

102.4

5

250/(3)

D

21

F/67

NMS/S

Autonomic Disturbances

Staphylococcus aureus/quetiapine, Thioridazine

35

102.0

13

75/(1)

R

22

F/10

NMS/S

Seizures

Staphylococcus aureus/Ziprasidone

44

102.4

15

160/(2)

R

23

F/71

NMS/S

Altered Mental Status

Streptococcus viridans/Escitalopram, Clonazepam, Amantadine

49

104

5

125/(2.5)

D

24

F/15

DKA

Fever/Polyuria/Polydipsia

Unclear

41

106

4

150/(2.5)

D

25

M/19

DKA

Seizures/Hyperthermia

Unclear

45

103

3

100/(2.5)

D