Mediator | Effect |
Histamine | Pruritis, urticaria, gastric hypersecretion, bronchoconstriction, increased vasopermeability, systemic hypotension |
Heparin | Local anticoagulation, osteopenia, osteoporosis |
Proteases | Fibrinogen degradation, stimulation of fibroblast proliferation, activation of procollagenase and tissue remodeling (degrade fibronectin) |
Cysteinyl leukotrienes (LTD4, LTC4, LTE4) | Increased vasopermeability, vasodilation, bronchoconstriction |
Prostaglandins (PGD2) | Vasodilation, bronchoconstriction, flushing |
Platelet activating factor | Increased vasopermeability, vasodilation |
Cytokines (TNF-alpha, TGF-beta, Nerve growth factor) | Activation of vascular endothelial cells, cachexia, fibrosis |
Growth factors (IL-3, IL-5, IL-6) | Mast cell and eosinophil proliferation, B cell proliferation with polyclonal increase in immunoglobulins and paraproteins |