Types

Gene

Age of Onset

Iron Burden

Liver

Bones and Joints

Heart

Pituitary

Type 1

HFE

≈40 - 60

+/+++

++

++

+

+

Type 2A

HJV

≈15

+++

+++

++

+++

++++

Type 2B

HAMP

≈15

+++

+++

++

+++

++++

Type 3

TFR2

≈30

+++

+++

++

+

++

Type 4A

SLC40A1

Any

+/+++

?

Type 4B

SLC40A1

Any

+/+++

++