Variable | Definition | Units |
Tw | Number of wild-type cancer cells that are sensitive to all treatments | cells |
Tcp | Number of mutant cancer cells resistant to cetuximab and panitumumaband that are sensitive to irinotecan and the hypothetical chemotherapy drug C2 | cells |
Ti | Number of mutant cancer cells resistant to irinotecan and that are sensitive to cetuximab, panitumumab and the hypothetical chemotherapy drug C2 | cells |
N | Concentration of NK cells per liter of blood | cells/L |
L | Concentration of CD8+ T cells per liter of blood | cells/L |
C | Concentration per liter of blood of other circulating lymphocytes not including NK cells, CD8+ T cells or regulatory T cells | cells/L |
E | Number of activated endothelial cells | cells |
R | Concentration of regulatory T cells per liter of blood | cells/L |
C1 | Concentration of the chemotherapy agent Irinotecan per liter of blood to which cancer cells become resistant | mg/L |
C2 | Concentration of a hypothetical chemotherapy agent per liter of blood to which cancer cells do not develop resistance | mg/L |
I2 | Concentration of IL-2 per liter of blood | IU/L |
A | Concentration of the monoclonal antibodies Cetuximaband Panitumumab per liter of blood | mg/L |
B | Concentration of TGF-βper liter of blood | IU/L |
S | Concentration of the tyrosine kinase inhibitor Sunitinibper liter of blood | mg/L |
F | Concentration of the monoclonal antibody Fresolimumabper liter of blood | mg/L |
M1 | Concentration of M1 Macrophages per liter of blood | cells/L |
M2 | Concentration of M2 Macrophages per liter of blood | cells/L |
T1 | Concentration of Th1 cells per liter of blood | cells/L |
T2 | Concentration of Th2 cells per liter of blood | cells/L |
I1β | Concentration of IL-1β per liter of blood | IU/L |
I4 | Concentration of IL-4 per liter of blood | IU/L |
I10 | Concentration of IL-10 per liter of blood | IU/L |
I12 | Concentration of IL-12 per liter of blood | IU/L |
Tα | Concentration of TNF-α per liter of blood | IU/L |
Iα | Concentration of IFN-α per liter of blood | IU/L |
Iγ | Concentration of IFN-γ per liter of blood | IU/L |
AI10 | Concentration of anti-IL-10 per liter of blood | mg/L |