Variable

Definition

Units

Tw

Number of wild-type cancer cells that are sensitive to all treatments

cells

Tcp

Number of mutant cancer cells resistant to cetuximab and panitumumaband that are sensitive to irinotecan and the hypothetical chemotherapy drug C2

cells

Ti

Number of mutant cancer cells resistant to irinotecan and that are sensitive to cetuximab, panitumumab and the hypothetical chemotherapy drug C2

cells

N

Concentration of NK cells per liter of blood

cells/L

L

Concentration of CD8+ T cells per liter of blood

cells/L

C

Concentration per liter of blood of other circulating lymphocytes not including NK cells, CD8+ T cells or regulatory T cells

cells/L

E

Number of activated endothelial cells

cells

R

Concentration of regulatory T cells per liter of blood

cells/L

C1

Concentration of the chemotherapy agent Irinotecan per liter of blood to which cancer cells become resistant

mg/L

C2

Concentration of a hypothetical chemotherapy agent per liter of blood to which cancer cells do not develop resistance

mg/L

I2

Concentration of IL-2 per liter of blood

IU/L

A

Concentration of the monoclonal antibodies Cetuximaband Panitumumab per liter of blood

mg/L

B

Concentration of TGF-βper liter of blood

IU/L

S

Concentration of the tyrosine kinase inhibitor Sunitinibper liter of blood

mg/L

F

Concentration of the monoclonal antibody Fresolimumabper liter of blood

mg/L

M1

Concentration of M1 Macrophages per liter of blood

cells/L

M2

Concentration of M2 Macrophages per liter of blood

cells/L

T1

Concentration of Th1 cells per liter of blood

cells/L

T2

Concentration of Th2 cells per liter of blood

cells/L

I

Concentration of IL-1β per liter of blood

IU/L

I4

Concentration of IL-4 per liter of blood

IU/L

I10

Concentration of IL-10 per liter of blood

IU/L

I12

Concentration of IL-12 per liter of blood

IU/L

Tα

Concentration of TNF-α per liter of blood

IU/L

Iα

Concentration of IFN-α per liter of blood

IU/L

Iγ

Concentration of IFN-γ per liter of blood

IU/L

AI10

Concentration of anti-IL-10 per liter of blood

mg/L