Question

Examples

1. Protein expression

2. Alternatively spliced mRNAs

3. Posttranslational modifications

4. Antigen receptor expression and specificity

・ Expression of tumor necrosis factor (TNF)-α protein, a driver of autoimmune tissue injury in RA and MS, is regulated posttranscriptionally by 3′ untranslated region AU-rich sequences.

・ Polyadenylation signal sequences frequently regulate protein expression posttranscriptionally .

・ Certain polypeptides with diametric functions, such as bcl-xS and bcl-xL, arise from alternative splicing of common RNA transcripts.

・ T and B lymphocyte activation are exquisitely regulated by phosphorylation and dephosphorylation of the antigen receptor-associated signaling complexes

・ Autoreactive T and B cells exist in heterogenous populations at frequencies of less than 1:10,000, making transcriptional profiling of T cell receptor and autoantibody gene usage uninformative