| Gene |
| 6 h |
|
| 24 h |
|
| Control | CL097 | Poly dA:dT | Control | CL097 | Poly dA:dT | |
| Pattern recognition receptors |
|
|
|
|
|
|
| TLR4 | 132 ± 8 | 136 ± 32 | 135 ± 26 | 131 ± 34 | 120 ± 10 | 128 ± 29 |
| TLR7 | 29 ± 4 | 28 ± 6 | 29 ± 7 | 24 ± 3 | 28 ± 7 | 25 ± 5 |
| TLR8 | 16 ± 5 | 15 ± 4 | 15 ± 4 | 15 ± 4 | 11 ± 4 | 15 ± 5 |
| IFIH1 | 593 ± 62 | 600 ± 138 | 955 ± 266 | 572 ± 87 | 652 ± 112 | 1067 ± 199* |
| DDX58 | 94 ± 2 | 107 ± 10 | 158 ± 34 | 86 ± 6 | 96 ± 28 | 201 ± 44* |
| Interferon response genes |
|
|
|
|
|
|
| MX1 | 323 ± 79 | 597 ± 149 | 564 ± 128 | 264 ± 49 | 654 ± 189 | 1911 ± 464** |
| IFNAR1 | 1657 ± 280 | 2893 ± 415* | 3404 ± 692** | 1558 ± 238 | 2247 ± 190 | 3311 ± 631* |
| Antimicrobials |
|
|
|
|
|
|
| MUC1 | 1762 ± 303 | 3073 ± 682* | 3553 ± 628** | 2001 ± 483 | 3505 ± 445* | 3938 ± 662* |
| SLPI | 24 ± 1 | 107 ± 35* | 44 ± 11 | 23 ± 4 | 71 ± 28* | 35 ± 12 |
| Cytokines |
|
|
|
|
|
|
| IL8 | 267 ± 35 | 1330 ± 248** | 412 ± 21 | 280 ± 37 | 481 ± 103* | 218 ± 36 |
| IL1B | 19 ± 2 | 306 ± 50*** | 39 ± 4 | 27 ± 7 | 97 ± 25* | 19 ± 4 |
| TNF | 19 ± 2 | 105 ± 31* | 54 ± 16 | 18 ± 4 | 25 ± 9 | 16 ± 4 |
| Reference genes |
|
|
|
|
|
|
| RN18S1 | 82 × 106 ± 28 × 106 | 83 × 106 ± 30 × 106 | 83 × 106 ± 29 × 106 | 89 × 106 ± 32 × 106 | 98 × 106 ± 40 × 106 | 87 × 106 ± 29 × 106 |
| ACTB | 351 × 103 ± 105 × 103 | 389 × 103 ± 134 × 103 | 369 × 103 ± 125 × 103 | 360 × 103 ± 116 × 103 | 367 × 103 ± 132 × 103 | 369 × 103 ± 123 × 103 |
| GAPDH | 98 × 103 ± 38 × 103 | 95 × 103 ± 35 × 103 | 94 × 103 ± 37 × 103 | 97 × 103 ± 34 × 103 | 105 × 103 ± 43 × 103 | 97 × 103 ± 33 × 103 |