Isolate Number

Resistance Pattern

PZA susceptibility testing

DNA Sequencing of pncA gene

MGIT

HRM (F)

Type of change

Codon number¤

Nucleotide change

Amino acid change

From

To

1

RIF, INH,STR, EMB, ETH, KAN, OFX

R

S

Insertion

173

-

C

Glu173Frameshift **

2

INH

S

R (F3)

No change

-

-

-

-

3

RIF, INH

R

S

Substitution

59

A

G

Ser59Pro **

4

RIF, INH, OFX

R

S

Substitution

14

A

G

Cys14Arg *

5

IHN, STR

R

S

Substitution

51

G

C

His51Asp **

6

INH, STR, EMB

R

R (F1)

No change

-

-

-

-

7

RIF, INH

R

R (F1)

Substitution

139

A

C

Va139Gly *

8

INH,STR, ETH

S

S

No change

-

-

-

-

9

RIF, INH

R

S

Substitution

14

G

C

Cys14Trp **

10

RIF, INH

S

R (F1)

No change

-

-

-

-

11

RIF, INH

R

R (F2, F3)

Substitution

14

G

C

Cys14Trp **

12

INH

R

R (F3)

No change

-

-

-

-

13

RIF, INH

S

S

No change

-

-

-

-

14

RIF, INH

R

S

Substitution

134

G

T

Ala134Asp **

15

RIF, INH

S

R (F3)

Substitution

139

A

C

Val139Gly *

16

RIF, INH, ETH

R

R (F3)

Substitution

12

T

C

Asp12Gly *

17

INH

S

R (F3)

Substitution

34

A

C

Tyr34Asp **

18

RIF, INH, EMB, OFX

R

R (F1, F2, F3)

No change

-

-

-

-

19

RIF, INH

R

R (F1, F2, F3)

No change

-

-

-

-