| Isotretinoin therapy | Placebo therapy | ||||||
| Before therapy | Day 14 | One month | Two months | Three months | Four months | Five months | Six months |
Mean | 13.133 | 10.567 | 7.6 | 5.5667 | 4.0667 | 5.9333 | 8.2 | 10.667 |
SD | 2.556 | 3.9277 | 4.9522 | 5.3219 | 4.2421 | 4.7119 | 4.3263 | 3.8714 |
P-value |
| 0.103 NS | 0.023 S | P < 0.001 HS | P < 0.001 HS | P < 0.001 HS | 0.046 S | 0.107 NS |