| Ligand | Energy docking with 2ITY (Kcal/mol) |
| 4b | −147.213 |
| 5N3 | −140.856 |
| 6c | −132.14 |
| 5b | −129.55 |
| 4c | −118.092 |
| Osimertinib | −115.633 |
| 5c | −113.682 |
| 6b | −112.186 |
| 3b | −111.724 |
| 7b | −108.864 |
| 6a | −106.005 |
| Rociletinib | −104.706 |
| 4a | −104.538 |
| 2b | −101.977 |
| 3c | −95.6706 |
| 3a | −91.0155 |
| 2c | −90.485 |
| 1b | −90.3229 |
| 5a | −88.3473 |
| 8b | −88.1895 |
| 3d | −86.0797 |
| 1c | −84.7441 |
| 7c | −83.6132 |
| 8a | −81.1525 |
| 2a | −80.798 |
| 7a | −78.8822 |
| 1a | −73.2927 |
| 8c | −70.8233 |