AG1* (n = 140)

AG2* (n = 292)

P value

Days of hospitalization before starting amikacin course therapy.

4.7 ± 9.4

3.8 ± 6.4

0.2

Total days of amikacin course (N)

4.6 ± 1.5

3.8 ± 1.6

<0.0001

Total amikacin doses per course (mg)

2709 ± 1256

2327 ± 1181

0.002

mg/day (per 24 hours)

600 ± 220

624 ± 207

0.2

mg/kg/day (per 24 hours)

9 ± 3.3

9.4 ± 3.4

0.3

Number courses changed amikacin dose

41(29)

57(20)

0.03

The day of the course changed amikacin dose

3.8 ± 1.6

3.2 ± 1.5

0.07

Starting amikacin doses

Number doses

3.5 ± 1.6

3.1 ± 1.5

0.02

Dose mg /day (per 24 hours)

648 ± 220

627 ± 197

0.7

Dose mg /kg/day (per 24 hours)

9.8 ± 3.4

10 ± 3.6

0.1

Changed amikacin dose

Number doses

2.6 ± 1.4

2.8 ± 1.6

0.6

Dose mg /day (per 24 hours)

567 ± 172

616 ± 211

0.4

Dose mg /kg/day (per 24 hours)

9.2 ± 3.0

9.9 ± 4.2

0.05